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  • Two European companies developing topical hair growth medications have filled up their patient rosters for their respective phase 2 trials last week. Cassiopea SpA announced via press release On October 8th, 2020 that 293 females between the ages of 18-55 have been recruited to participate in a 6 month study to test different concentrations of clascoterone (one of them is the standard 7.5% Breezula concentration) against minoixidl 2% and placebo. Results are expected in Q2 2021 and this should be one of the most interesting studies for all female patients seeking new treatments to grow hair. - Source: Internet
  • A team of researchers from the University of Erlangen in Germany have discovered a new molecule, specifically a soluble form of the CD83 protein, which they believe will be useful for hair growth. The team was awarded with the prestigious m4 Award from the Free State of Bavaria for their research. This award provides prize money that the team will use to form a new company called “MalliaBiotech” to further develop their hair growth protein. We will be following the progress of this story which has been making headlines in German news outlets over the weekend. - Source: Internet
  • A long promised study on the Minoxiboost product aka SULT1A1 from Applied Biology was published in the Journal of Cosmetic Dermatology earlier this week on June 16th. The study titled “SULT1A1 (Minoxidil Sulfotransferase) Enzyme Booster Significantly Improves Response to Topical Minoxidil for Hair Regrowth” includes Drs. Jerry Shapiro, Rodney Sinclair, Rachita Dhurat, and Andy Goren as authors, among others. - Source: Internet
  • Per a company press release from this morning, Histogen has announced preliminary results from its phase 1b/2a trial for men with androgenic alopecia which began earlier this year. No statistical data was shared in the release other than the mention that patients treated with HSC demonstrated “separation” in total hair count from patients who received placebo injections. Histogen CEO Richard Pascoe states that the company is looking forward to reporting the full results after a week 26 assessment has been completed by all patients in early 2021. Let’s hope that a statistically significant result is found over the next 2 months. - Source: Internet
  • These assumptions and their attendant fears are explicitly encouraged by many supplement and cosmetic companies as a way to more effectively market their own products. Vegamour’s website, for example, includes a list of medical-grade ingredients that its products do not include, alongside context-free lists of the most unpleasant side effects that have ever been attributed to those ingredients, even if those side effects are quite rare. The site does not mention any potential side effects of its own products. Drug manufacturers are legally required to track and disclose side effects, but cosmetic companies are not. - Source: Internet
  • COVID-19 infections are only part of the picture. Throughout the pandemic, millions more Americans have suffered devastating emotional stress even if they’ve never gotten sick: watching a loved one die, losing a job, going to work in life-threatening conditions, bearing the brunt of violent political unrest. Feelings can have concrete, involuntary physical manifestations, and these traumas are exactly the kinds that leave people staring in horror at the handfuls of hair they gather while lathering up in the shower. - Source: Internet
  • Most men fear losing their hair completely as they grow older. Their fear is not irrational since receding hairline and balding are very common among men once they enter their late 20s. Although it doesn’t impact life much, men tend to fret about their appearance and dating prospects as they notice a receding hairline. - Source: Internet
  • More than 50% of men have significant signs of hair loss at the age of 50 and it reaches 4 out of 5 men by the age of 70. Moreover, nowadays, the younger generation starts to fight hair loss at an earlier age, compared to a few centuries back. According to research conducted by the NHS, 25% of men, suffering from Male Pattern Baldness (MPB), start losing hair by the age of 20-21. The reasons for hair loss are very individual and we have mentioned some of them below: - Source: Internet
  • A long standing and intriguing drug development program by JW Pharmaceutical is picking up steam again. Its history includes a research collaboration with Dr. George Cotsarelis of UPenn. Head to the Articles page to read more about JW’s candidate compound which is focused on regenerating hair follicles through stem cell activation and proliferation. - Source: Internet
  • When men notice their receding hairline, they often become very self-conscious. This is because they think they are losing attractiveness and are beginning to show signs of ageing. Therefore, any balding man tries to find a fast and effective solution. Firstly, he evaluates all the pros and cons of being bald, secondly, he looks for the best way to shave their heads and finally makes a decision! - Source: Internet
  • As the comment from the 23-year-old Reddit user above illustrates, Male Pattern Baldness can strike at any time after puberty, and is not actually a sign of growing old. Nor is it a guaranteed precursor to total baldness. Hairloss can happen over many years or decades, and in a way those first signs of hair loss are actually a helpful warning system for men who want to keep their hair. - Source: Internet
  • In their press release, OliX CEO Dr. Dong Ki Lee shared the following statements: “Due to topical administration, our investigational therapy acts directly on the affected area and is rapidly degraded upon exposure to the blood, so it’s free from major systemic side effects such as sexual dysfunction caused by conventional hair loss therapeutics. Building on our experience evaluating RNAi therapeutics for skin diseases, we plan to initiate clinical trials of OLX104C by 2022.” Hopefully the timeline to human trials will be as swift as possible for this interesting new therapy. - Source: Internet
  • Your doctor may prescribe the breast cancer drugs raloxifene or tamoxifen as off-label treatments for gynecomastia. Switching medications. If a doctor suspects that a drug you’re taking may be causing your gynecomastia, they may switch your medication or lower your dose. - Source: Internet
  • Omega Therapeutics of Cambridge, MA completed their initial public offering (IPO) two weeks ago and is now publicly traded on Nasdaq. The company is developing a novel therapeutic platform called “Omega Epigenomic Programming”, which involves a new class of DNA-sequence-targeting, mRNA-encoded programmable epigenetic medicines. Alopecia happens to be a disease indication in Omega’s pipeline with the SRFP1 gene specified as the target. Most will remember the SFRP1 protein was highlighted in research done at the University of Manchester in 2018. - Source: Internet
  • But trichologists and doctors alike also assume that, beyond genetics, lifestyle factors also contribute to hair loss. “Something men don’t really talk about is emotional health and wellbeing, but that’s a trigger,” Hill says. “So is your diet—a lot of times, men have high-protein diets without lots of greens or folic acids, which are essential in making hair follicles and protein.” Dr. Bauman also adds that poor sleep, some medications, and smoking may worsen things, too. - Source: Internet
  • The saga between Replicel and Shiseido may not be ending anytime soon. Today, Replicel issued a press release announcing that they have terminated Shiseido’s license to commercialize RCH-01. Shisiedo happens to currently be in the middle of a clinical trial involving RCH-01 with plans to commercialize the treatment if successful. The Shiseido RCH-01 trial article is currently stickied to the top of the Articles page with a link to today’s press release. - Source: Internet
  • “We are working to train and register clinical partner and banking associate clinics as authorised procurement centres for follicle banking. We already have authorised centres in UK, California, Texas, Southern Florida and expect additional ones in Massachusetts, North Carolina, Colorado, Sydney Australia and Melbourne Australia soon. Additional sites in Canada and New Zealand have been delayed by the Covid-19 situation. Banking was paused earlier in the year because of lockdowns but has started up again now - Source: Internet
  • Dr. Ralf Paus and the team from the Monasterium Laboratory in Germany are hosting a world class training course in hair follicle research this June. The training course will feature a multitude of researchers who will give lectures on specifics aspects of hair biology and therapeutic targets. Visit the Monasterium Education page for more information on this course. - Source: Internet
  • A new article has been published on CarthroniX, an interesting biotech startup out of California which is developing small molecule therapies for tissue regeneration. One of CarthroniX’s interests is hair growth and they have previously published a paper on using specific molecules to stimulate lactate production which in turn activated hair follicle stem cells and the hair growth cycle. Read more about CarthroniX and their lead candidate RCGD423 on the articles page now. - Source: Internet
  • On January 24, 2022, dNovo issued a press release to announce a successful round of fundraising from several Silicon Valley-associated VC firms and angel investors. dNovo was able to net $2.7M in their seed round, which is a significant raise for a hair growth biotech. This funding will allow dNovo to expand their development efforts into a more clinical direction. Today’s press release also hints at dNovo’s interest to secure an industrial partner to help really accelerate the development of their hair regeneration therapeutic. - Source: Internet
  • Weight gain in later life may be particularly noticeable in the breast area, also resulting in larger breasts. This is known as pseudo-gynaecomastia. Many men accept this change as another part of the ageing process. - Source: Internet
  • “Cut your hair very short or shave it off. Have photos on your profile reflecting your current hair, so it’s not a surprise. My partner (29M) is currently balding, and it is not attractive when it grows out too much. I have had to give him subtle hints about ‘hey! Maybe time for a haircut?’ Lol.” –Minimum_Kale_15 - Source: Internet
  • Contrary to popular wisdom – and the existence of super-macho baldies such as Bruce Willis – the propensity to lose your hair doesn’t make you any more of a man. Bald men are no more virile and they don’t have higher testosterone levels, though they do tend to have hairier arms, legs and chests. Perhaps most surprisingly, bald men don’t actually have any fewer hairs on their heads. - Source: Internet
  • There are two verified, safe, and affordable treatments for hair loss that we’re not allowed to say here, because advertising prescription medication in Australia is illegal. This law, which is generally good because it protects consumers from predatory tactics 99 per cent of the time, is actually the reason these “clinics”’ can exist in the first place. Not having to mention the names of their treatment options allows many clinics to operate on a platform of misinformation, keeping patients in the dark. - Source: Internet
  • By reducing the production of DHT, clinically-proven products recommended as part of a personalised regrowth plan by a hair loss specialist can stop hair falling out. They can also help to stimulate regrowth, improving hair density. The key is to act quickly, and start fighting back as soon as the thinning or receding is first noticed. A swift intervention can make all the difference and many Belgravia clients tell us they wish they had started sooner! - Source: Internet
  • In patients who only need liposuction to correct their enlarged male breasts, return to exercise and work is typically less than one week. For patients who need surgical removal of the excess breast tissue, it can take between two to four weeks to heal enough to tolerate routine activities. In my practice, my patients are able to go back to work after surgery at 7-10 days. They are able to get back to the gym for cardio at 2 weeks and weightlifting at 4 weeks barring complications from surgery. - Source: Internet
  • Accordingly, across the globe, we spend $3.5bn (£2.7bn) on baldness cures every year. That’s more than the entire national budget of Macedonia or, as Bill Gates pointed out last year, significantly more than we spend on the control of malaria (just $200m (£154m) per year). - Source: Internet
  • Note that this does not prevent other doctors from trying verteporfin in a human patient sooner if they feel it’s a reasonable attempt. I will follow up with Dr. Longaker in the future about the results of the pig studies which are considered the gold standard of preclinical skin models. - Source: Internet
  • Women who have thin hair with no bald patches may have a hormonal imbalance caused by excess levels of androgens, a class of hormones that includes testosterone. Signs of androgen excess include hair loss and baldness; hair growth on the face, chest, or abdomen; and irregular menstrual periods and acne. A blood test can reveal an elevated androgen level. - Source: Internet
  • “There are so many triggers that can create balding, so it’s important to have a clear understanding of what actually impacts the process,” says Palm Beach trichologist Bridgette Hill. (A trichologist is a hair and scalp specialist who is not a doctor.) “There is no reason that balding has to be a reality in the 21st century.” - Source: Internet
  • Avoid product “build-up”. Plenty of folks don’t like to wash their hair every day and there’s nothing wrong with letting some natural oils recover in your scalp before you hit it with shampoo. But if you’re using a product to keep your hair in place, make sure it comes out before any more goes in. Even if this means washing with only water every day, it’s best to create a clean environment to encourage healthier follicles. - Source: Internet
  • A new article has been published featuring two new companies in the hair growth game. One of the companies, Rise Technology, is a spin-out of the University of Wisconsin at Madison based on Dr. Wang’s research using electrical stimulation devices which fit into baseball caps. The other company, HaplnScience, is taking a completely new approach to hair regeneration by targeting a protein that may have a significant anti-aging effect on skin and hair follicles. Head to the main Articles page to read more. - Source: Internet
  • “I just don’t buy into the myth that a shaved head is better than the balding look 100% of the time. If you don’t have the dome or jawline for it a shaved head just looks weird, like you’re a giant toe. A tasteful haircut can make a balding man look good without shaving it like everyone else does.” - Source: Internet
  • The most prominent hair growth research company in Asia and probably the most diverse hair research company in the world, Epibiotech of South Korea, recently completed an interview with Follicle Thought. Epibiotech’s research focus is the creation of an injectable dermal papilla cell therapy which can create significant hair growth/regrowth. They have been working on various methods to maintain the potency of dermal papilla cells when cultured outside the body. Ultimately, a clinical trial will validate whether the EPI-001 cell therapy performs better than previous industry attempts. Head to the main Articles page to read the Epibiotech 2021 Interview and hear more about their clinical trial plans. - Source: Internet
  • Kintor Phatmaceutical’s most advanced AR antagonist drug for the treatment of androgenic alopecia is making significant progress in both the US and China. Today, it was announced that the FDA has approved a phase 2 trial of pyrilutamide in the US. There’s also important news brewing around Kintor’s phase 2 and upcoming phase 3 trial in China. Head to the main Articles page to read an updated article on Kintor while it is stickied. - Source: Internet
  • Researchers at Yonsei University in South Korea led by Nahyun Choi PhD have identified yet another key protein which could be developed into a new therapy for hair loss. The latest study on the epiregulin protein (EREG) was published as the cover paper of the September 2020 print version of Cell Proliferation. In the study, it was found that EREG has a positive effect on the hair growth cycle by activating the phospho-EGF receptor and the ErbB4 antibody in epidermal cells. Choi, who is also a lead researcher at the Stemore company, told the Korean media site Money Today that epiregulin is “expected to be developed as a cosmetic material as well as a hair loss treatment agent (drug).” - Source: Internet
  • This simple test measures the severity of hair loss. During a pull test, a dermatologist grasps small sections of hair, about 40 strands, from different parts of the scalp and gently tugs. If six or more strands fall out, you have what’s known as active hair loss. - Source: Internet
  • “A man holding onto his hair when its clearly balding? Absolutely a deal breaker. A man who embraces it and just shaves his head? Not a deal breaker, confident bald men are so sexy.” –XenaDazzlecheeks - Source: Internet
  • In the latest clinical trial of HST-001 aka HSC, Histogen did not deliver the results we were looking to hear. After 26 weeks of observation, patients receiving injections of HST-001 did not show a statistically significant increase in total hair count compared to patients who received placebo injections. The news is not optimal, but somehow this is apparently not the end of the road for HSC. Head to the Articles page for the full story. - Source: Internet
  • Maintaining a safe, truthful environment is an uphill battle. “To keep this group running and to keep it free from shills and people who are trying to take advantage of it and spammers, it’s a lot of work,” Tala said. She and the other mods walk a difficult line: For the group to be helpful to as many people as possible, it has to feel welcoming and nonjudgmental, and it has to be free of people who might be trying to sell something. For the group to actually help, the moderators and regular commenters have to find ways to tell people who have spent so much money on “natural” cures that they maybe have been duped, without making them feel stupid or defensive. They teach people the basics of hair’s growth cycle, what to look out for when evaluating a scientific study, and which treatments are known to be effective for the type of hair loss they suspect they have. - Source: Internet
  • Thousands of years later, we’ve moved on from garlands and revolting concoctions to expensive creams, tonics and shampoos, and last resorts of toupes, pills and surgery. Today you can attend a hair loss clinic, sign up for hair-loss counselling and it’s not unusual to see adverts telling balding men to “see their doctor”. Papers discuss balding in epidemic terms, meanwhile the phenomenon even has a new scientific-sounding name, “androgenic alopecia”. If you didn’t know otherwise, you might think it was a medical condition. - Source: Internet
  • When should I see a doctor for gynecomastia? Gynecomastia doesn’t typically cause any symptoms other than tenderness around the breast, but it can be a cause of mental distress. It’s a good idea to visit a medical professional if you experience discharge from your nipples, have swelling, or have a significant amount of pain. If you think you could have a medical condition such as a tumor in your testes or hyperthyroidism, it’s also important to see a doctor. A doctor may be able to help you find the underlying cause of your gynecomastia and help you find the best treatment. - Source: Internet
  • A pharmaceutical company from Japan which specializes in bacteria-based therapeutics has recently published an interesting patent related to hair growth and hair loss prevention. Unlike most patents, this one contains several before and after images of human subjects who apparently tested the product. At least one result shown would be considered extremely significant if it were proven to be authentic. Head over to the main Articles page to read more about this enigmatic patent from Nichinichi Pharmaceutical Co. - Source: Internet
  • Several people took the time to send me the Concert Pharmaceuticals phase 3 trial press coverage which includes some very noteworthy photography. The only catch is that the drug CTP-543, which is a JAK inhibitor, is intended for alopecia areata and not androgenic alopecia. Nonetheless, this may be a supportive new development for those seeking treatments for AA. CTP-543 is a modified form of ruxolitinib. - Source: Internet
  • I reached out to Dr. Lu Le recently to ask if he was still pursuing the Krox20/SCF research as potential treatments for hair loss and hair graying. I was surprised to get this quick response from him as follows: “Yes, we are expanding our research on those areas. Will send you our publications once they got accepted.” - Source: Internet
  • Our favorite hair researcher from Southern California has made a notable new discovery. Yesterday, on June 30, 2022, the study Hedgehog signaling reprograms hair follicle niche fibroblasts to a hyper-activated state was published in the Developmental Cell journal. The study demonstrates that Plikus et al identified the SCUBE3 protein as a potent stimulator of hair follicle stem cells and the hair growth cycle. Plikus described that SCUBE3 is secreted by dermal papilla cells as a signaling molecule to interact with the neighboring stem cells. - Source: Internet
  • First, I want to say this: I’m glad you’re here. Hair loss is something that most guys will experience in their lives, and if more of us talked about it instead of joking about it, maybe we’d all have better information. According to the American Hair Loss Association, two-thirds of American men will experience some degree of appreciable hair loss, with 85 percent of men “significantly thinning” by the age of 50. About 25 percent of men who experience hair loss begin the process before they reach the age of 21. In other words, this is a nearly universal experience—which makes the stigma surrounding hair loss all the more confusing. - Source: Internet
  • On January 5, 2022, Technoderma Medicines announced the successful completion of its phase 1 trial for the drug TDM-105795 in which no adverse events were reported. Also announced was the initiation of recruitment for a phase 1b trial of TDM-105795 which is designed to be a dose escalation study. In this phase 1b trial, the goal is to identify the highest/safest dose of TDM-105795 to be used in a further phase 2 clinical trial. According to Technoderma’s website, the phase 1b trial will take place over a period of only 28 days, meaning it is very likely that TDM-105795 will begin recruitment and begin dosing patients in a phase 2 trial later this year. Good news and progress from Technoderma Medicines. - Source: Internet
  • Earlier this week, Follicle Thought had the scoop announcing a new drug entering a phase 1 clinical trial in Q3 2022. CU-40101 by Cutia Therapeutics is set to be trialed in male subjects by the year’s end and the study is listed on the Clinical Trials.gov portal. Is this your first time hearing about the article? Make sure you are subscribed for email notifications when new articles drop by entering your email on the right sidebar or bottom sidebar on mobile browsing. You can also bookmark the front page of Follicle Thought for quick access. - Source: Internet
  • A video interview featuring Maksim Plikus and his fascinating SCUBE3 research has surfaced from a news organization based in Ohio, of all places. Spoiler alert: Maksim appears to have told the journalist that SCUBE3 is intended to become a therapy which could potentially be “microinjected into scalps to reverse baldness.” Here’s the video shared by Spectrum News 1. After clicking “play” click “ask later” to see the video. - Source: Internet
  • What science can confirm is that the exact trigger for male-pattern hair loss is a hormone called dihydrotestosterone, otherwise known as DHT. “This comes from testosterone that’s naturally in your body, but if you have male-pattern hair loss, what you’ve inherited is a sensitivity to DHT in your hair follicles,” says Dr. Alan Bauman, a full-time, board-certified hair restoration physician. Basically, he explains, this sensitivity to DHT causes a “miniaturization of the hair follicle,” which leads to the overall weakening of hair growth. This manifests itself as that all-too-common receding hairline and thinning in the crown of your head (the “bald spot”). - Source: Internet
  • If you’ve never gone from normal hair to bald spots in a matter of weeks, you might be tempted to dismiss this as vanity. But people value their hair because the society they live in tells them it’s important. Women in particular have been told for centuries that their hair is their glory, which paraphrases a biblical edict about long hair as a demonstration of righteousness before God. A full head of hair, Donovan, the Whistler dermatologist, pointed out, is still a crude, unscientific shorthand for youth, for healthy living, for vitality. Losing it can send people into a profound depression, or make them ashamed to leave the house. - Source: Internet
  • Around the start of the new year, a company which has been working under the radar since 2018 launched their website and announced themselves to the world. That company is dNovo of Northern California, USA. Harnessing the power of cellular reprogramming, an advanced new therapeutic technique, the company seeks to regrow hair follicles using stem cells. Head to the Articles page and dNovo’s website to get a full rundown of what the company has shared with us so far. 2022 is off to a good start. - Source: Internet
  • Yesterday, Cassiopea issued a press release sharing some details from the results of its phase 2 trial of clascoterone for the treatment of female androgenic alopecia. The study comprised 293 women aged 18-55 who received a twice daily dose of clascoterone or vehicle over a 6 month period. According to the release “only the subgroup with women less than 30 years of age receiving twice daily application of 5% clascoterone solution showed statistically significant differences from baseline in TAHC at Month 6.” This would imply that the “complete” phase 2 trial itself did not reach statistical significance; it’s a way to share the news in a positive light. - Source: Internet
  • Odds are, if you’re reading this, you are quite literally already balding or thinning—even if you don’t think you can see it. But don’t panic! First, it’s possible to look great bald. But secondly, there’s a lot you can do. - Source: Internet
  • There are no guidelines on which treatment should be considered first. However, tamoxifen is usually preferred. While you’re taking any of the drugs listed you may experience side effects, so they should only be taken following a thorough discussion of their benefits and risks. - Source: Internet
  • However, it can take some time before the breasts flatten out. If you’re finding this embarrassing or you’re worried, see your GP. They will usually be able to confirm if you have gynaecomastia. Occasionally you may be referred to a breast clinic for further assessment. - Source: Internet
  • When I first began my own search for answers, the avalanche of hair-loss products under which Google immediately buried me was disorienting and overwhelming. It wasn’t just the beautiful, full-color photos of luxuriously packaged pills and oils that Google threw at me up front, but how the internet kept the score, using the admission that I was losing my hair to stalk me across time and platforms in a way seemingly designed to wear down my defenses. For months on end, those products and many more followed me around the internet, interrupting my friends’ Instagram stories of their latest cooking projects and slipping between my extended family’s Facebook posts about their kids’ first day of school. - Source: Internet
  • Also announced on October 8th, Follicum has completed the enrollment of 200+ male patients who will be administering different concentrations of the peptide FOL-005 or placebo once daily over a period of four months. The last patient enrolled is scheduled to complete the regimen by the end of January 2021. Results from the trial are expected around the end of Q1 2021. The first half of 2021 should have some important news to share for the hair seeking community. - Source: Internet
  • Older men may worry that the changes to their breasts are a sign of cancer. Having gynaecomastia doesn’t increase your risk of developing breast cancer, but it’s still important to be breast aware. Go back to your GP if you notice any other changes regardless of how soon these occur after your diagnosis of gynaecomastia. - Source: Internet
  • In the United States, cosmetics and dietary supplements occupy a separate legal category from drugs. Their efficacy claims are far less regulated, which allows the manufacturers of nonmedical hair-growth products to make enticingly vague promises that would be more heavily scrutinized and caveated when made by a pharmaceutical company. Paradoxically, this freedom from regulatory surveillance can lead potential customers to assume that these products must be superior overall. The difference can seem implicit in the distinction from pharmaceuticals—if this class of products weren’t safer, more natural, and just as effective, wouldn’t the same level of governmental caution be applied to them? Can’t we infer something from its absence? - Source: Internet
  • Regarding its efficacy in regrowing hair, many claim that it works miracles, however only one study has ever been conducted and the group used was both very small (by scientific study standards). The study also only used patients with alopecia areata; a reasonably rare type of patchy hair loss that differs from androgenic alopecia (male pattern baldness). This is important to note as the causes of alopecia areata are different to the causes of male pattern baldness, and the number of people affected by each condition are hugely disproportionate to each other. - Source: Internet
  • Stemson CEO Geoff Hamilton is scheduled to deliver the keynote address at the 2021 Global Hair Loss Summit titled “Developing Induced Pluripotent Stem Cell Technology to Engineer a De Novo Supply of Hair Follicles to Treat Hair Loss.”’ Hamilton be joining many other hair restoration professionals to give presentations at the Summit, which is tailored towards the hair transplantation industry. The GHLS 2021 is taking place December 11-12, 2021 and will be presented virtually; registration cost is listed at $499. It would be interesting to hear what Geoff says to say during his presentation, although, I would be surprised if anything distinctively different from his Follicle Thought interview will be shared. - Source: Internet
  • Is this the end of SM04554 aka dalosirvat? Some readers brought to my attention this morning that SM04454 has been removed from Biosplice’s pipeline page. There is no longer a mention of the drug or an androgenic alopecia program on the Biosplice (formerly Samumed) website. While there has been no official statement from Biosplice about the dissolution of its AGA program, this recent occurrence coupled with a long delay in communication following the completion of its phase 3 trial of SM04554 in January are not promising signs. It’s possible that we have seen the last of SM04454. Stay tuned for any further clarification from the company. - Source: Internet
  • Medical treatments for gynecomastia Treatment for gynecomastia usually consists of targeting the underlying condition. Some nonsurgical treatments a doctor may recommend include: Off-label medications. Your doctor may prescribe the breast cancer drugs raloxifene or tamoxifen as off-label treatments for gynecomastia. - Source: Internet
  • There have always been people who have chosen to become benefactors for medical and environmental issues. Despite affecting millions of people, hair loss is still yet to receive a significant contribution from such people. Who could become this great benefactor? Please tag them. — Follicle Thought.com (Hair Growth Research) (@FollicleThought) August 2, 2022 - Source: Internet
  • It has dawned on me once again that there should be more done to spread the message of AGA cure research to philanthropists and those with resources. This message needs to be spread by members of the audience as well and not just me. Can you share this message, either directly or paraphrased in your own words, with someone who can make a difference? It is important for more people to get involved now. - Source: Internet
  • For several reasons, many people don’t get much straightforward information on any type of hair loss, TE and beyond. For one, hair loss doesn’t really lend itself to the format of the modern American doctor appointment. Finding the right diagnosis can be a detailed, time-intensive process. “You cannot do everything for a hair-loss patient in a 15-minute visit,” Senna said, and that’s all the time many doctors get to have with their patients. Seeing a dermatologist who specializes in hair loss, she said, is more likely to get patients a visit of at least 30 to 45 minutes and a more detailed, empathetic evaluation—if a patient can figure out to go to such a dermatologist in the first place. - Source: Internet
  • Moreover, hair loss typically isn’t a particularly urgent problem for practitioners who may have many other types of health concerns coming into their office. Most hair loss that isn’t triggered by some kind of trauma is caused by androgenic alopecia, or AGA, often known as male or female pattern hair loss. It’s passed on genetically and has no cure, although some safe treatments are widely available. Doctors busy with other things may shrug their shoulders at patients who have incurable conditions that aren’t physically dangerous or painful. And for panicking patients who hear “Wait it out” or “Buy some Rogaine,” that recommendation may feel dismissive or inadequate, even if it is correct. - Source: Internet
  • It is a conceivable notion that Stemson may be interested in utilizing the Specials regulation as a way to test and fine-tune its hair regeneration therapy before conducting a full-fledged clinical trial in the UK. This announcement comes on the heels of a $7.5M investment that Stemson received from Allergan Aesthetics and Fortunis Capital, which is an investment firm based in the UK. Geoff Hamilton, CEO of Stemson, shared this statement regarding the potentials of expanding into Great Britain: “The UK is on our short list with its world class scientific talent and infrastructure, and I know Fortunis Capital certainly believe we will find full support for this level of scientific innovation in the UK.” ? Interesting stuff going on here. - Source: Internet
  • Another group of women finds hair loss a secondary and non-significant factor. Moreover, they pay much more attention to a man’s sense of humour and other personal characteristics such as intelligence, sociability, confidence rather than the hair on the head. A reasonable woman would never choose his soulmate based on his facial appearance. And for those who will, they hardly deserve your attention. - Source: Internet
  • As you noticed, I’ve taken my time in sharing this news on Follicle Thought. The research is very interesting, but only time will tell if a single mRNA can become a truly effective hair growth therapy. A topical ointment involving miR-218-5p is feasible in the future, but it is a long ways off from this year. Cheng’s next step is to test miR-218-5p’s effect on hair growth as a solo ingredient. We’ll keep an eye on this as things progress. - Source: Internet
  • Two new companies working on hair growth were recently announced by Follicle Thought. Life Code AI is an artificial intelligence company working in various therapeutic areas including androgenetic alopecia, Aranda Pharma is a small biotech startup with a novel androgen receptor inhibitor in its pipeline. Head to the Articles page to read more about these two new interesting companies. - Source: Internet
  • The pandemic likely put this process into motion thousands—if not millions—of times. It’s a challenge that the supplement and cosmetic industries were well positioned to meet; beauty supplements and topical cosmetics are now often sold alongside each other, not just in luxury department stores and beauty emporiums such as Sephora and Ulta, but at Target or via Amazon’s recommendation algorithm. That these products don’t work matters very little to their profitability. In that way, this is a story that predates the pandemic by at least a century. When real, reliable information is hard to come by—in this case, when it is cut off from the general public by the structural limitations of the American health-care system—there will always be a market for new products with hollow promises. - Source: Internet
  • Dozens of women said, quite often the face and the head shape of a man is something which looks perfect with a bald head. Usually, by saying this, women refer to celebrities such as Bruce Willis, Patrick Stewart, Jason Statham, Dwayne Johnson. Also, the answer to the question “Is a shaved head unattractive?” was a solid “no”. - Source: Internet
  • Dr. Maksim Plikus, a Professor of the University of California at Irvine, is the latest scientist to found his own company in hopes of treating or curing baldness. Plikus recently told the media organization dot LA that he hopes to put a topical solution on the market which would require less than daily applications to be useful. The name of Plikus’ startup company is Amplifica. The name has a nice ring to it, let’s hope that its clinical results will also be as pleasant. - Source: Internet
  • Another reassuring fact for bald men - women appreciate when men shave their head rather than try to camouflage their hair loss. It is seen as a self-confident act which makes them admire the man. Moreover, women and shaved headed woman say what matters isn’t hair, but confidence: in that case hair or lack of it does not matter that much. Women like when men take care of themselves, thus a sleek and well-groomed look is always appreciable․ - Source: Internet
  • In simple terms, Replicel is looking to identify the most potent and inductive cells within the dermal sheath cup of a hair follicle in order to precisely extract them and utilize them in the culturing process of RCH-01. The overall goal is to improve the hair growth capability of RCH-01. I have learned from a scientist at Replicel that improving the inductivity of RCH-01 in this manner would not require them to restart any clinical trial process as long as the cells are still derived from the dermal sheath cup. We wish them well. - Source: Internet
  • So, for the questions “Do women like bald men?” the overwhelming majority of women gave positive answers. 87.5% of women of different ages and nationalities surveyed find bald men attractive compared to only 12.5% of women, who gave negative answer. - Source: Internet
  • It sounds as if there is some sort of nano-encapsulation technology involved which may be used to preserve the stem cells or keep a mixture of cells intact. This may very well be a “hair cloning” type of therapy where a concoction of hair/skin stem cells are cultured and implanted back into the skin to form new hair follicles. In time, we will hopefully find out more about this approach. - Source: Internet
  • Exercise tips for gynecomastia It’s a myth that exercising a certain part of your body causes you to lose more fat in that area than other parts of your body. For example, if you do pushups, you won’t lose more fat from your chest than if you burn the same number of calories doing squats. Including more aerobic exercise in your workout program can help you lower your overall body fat percentage. The type of exercise you do isn’t as important as the length, intensity, or duration. Some ideas include: brisk walking - Source: Internet
  • I did what everyone does: I Googled my symptoms. At the very top of the search results, a colorful carousel of vitamins, serums, shampoos, and direct-to-consumer prescription services appeared; a so-small-you-could-miss-it disclosure in one corner signaled that these products weren’t real search results, but advertising. Well below them, the real results weren’t much better—WebMD, a bundle of Reddit threads, medical journals whose articles would cost me $50 a pop, factually thin blog posts, natural-health grifters touting hair-growth secrets that doctors didn’t want me to know, product reviews that weren’t labeled as ads but for which someone had almost certainly been paid. I pressed on to gather whatever reliable-looking information I could find, itself full of terms I didn’t fully understand—effluvium, minoxidil, androgenic. - Source: Internet
  • This is an extremely fascinating development and you can be sure that Follicle Thought will be reporting on the announcement Wednesday. For clarity, the official Riken website has created a 2021 update which verifies the legitimacy of the new Riken Twitter account. Let’s hope for some amazing news this week. ? - Source: Internet
  • This level of confusion—including my own—is, frankly, infuriating. Eighty percent of men and about half of women experience some form of hair loss in the course of their life. TE was first described in the 1960s, and it has long been a predictable side effect of surgery, changing medications, crash dieting, childbirth, bankruptcy, and breakups. The way TE resolves for almost everyone who doesn’t already have chronic hair-loss issues is that the hair eventually grows back—plain and simple. You would think, at some point, that someone would tell you not to panic if you lose some hair after something intense happens—that even if you shed for months, it will grow back eventually, and there’s no need to do anything but wait. - Source: Internet
  • Below is a tweet I wrote over the weekend which received a good response. It’s a sentiment that’s crossed my mind several times over the years as I have become better acquainted with the Follicle Thought audience. We’d all like to see a positive change. Please get in touch through the Contact page if you are interested in making a positive change. - Source: Internet
  • suits with pinstripes Improve your lifestyle habits, as needed Some lifestyle habits can contribute to increased body fat. People who are overweight can often have more fat throughout the body, including around their chest, than people who are not overweight. Increased body fat can also contribute to lower testosterone levels by increasing aromatase activity. Some lifestyle habits you can make to improve your hormone levels include: minimize alcohol consumption - Source: Internet
  • All of these factors have led to what Jeff Donovan, a hair-loss dermatologist in Whistler, British Columbia, described to me as a “mountain” of new hair-loss patients since the pandemic began. What exacerbates the difficulty of dealing with hair loss for many patients, he and the other doctors I spoke with told me, is just how little good, if any, information on the condition the people coming into their offices are able to assemble, even if they broached the issue with other kinds of doctors in the past. “They don’t know what’s going on, they don’t know why they’ve spent so much money, and they’re just so confused," Maryanne Makredes Senna, a co-director of Massachusetts General Hospital’s hair-loss clinic, told me. “It’s like, ‘I don’t know what to believe, and I went to this doctor and they made me feel like I was crazy.’” The doctors I spoke with said that their patients typically come to them after having seen at least a handful of other practitioners, and sometimes as many as 15. - Source: Internet
  • siRNAgen Therapeutics is hoping to release a cosmeceutical hair growth product in the United States in 2022 or 2023. The company has completed two clinical trials of their CosmeRNA product in male and female pattern baldness which produced a positive result. Results from these trials were published in the Nature journal today. siRNAgen also says there is an avenue to develop their siRNA as a pharmaceutical treatment as well. Head to the Articles page to get the full scoop. - Source: Internet
  • Tamoxifen is usually given as a treatment for breast cancer. However, studies have shown that it’s also effective in treating painful gynaecomastia by lowering the amount of oestrogen in the body and reducing the size of the breast(s) in men. It’s given as a tablet and your specialist will advise you what dose to take and for how long. It can have several side effects including nausea and loss of libido (sex drive). - Source: Internet
  • “The company’s technology showed improvement in hair loss and enhanced the growth by implanting stem cells cultured under specific conditions into the body through capsules. Stem cells inserted in the capsule are designed to improve only hair growth without side effects.” - Source: Internet
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